Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance
نویسندگان
چکیده
منابع مشابه
Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.
Statins reduce lipid levels and are widely prescribed. Statins have been associated with an increased incidence of type 2 diabetes, but the mechanisms are unclear. Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome, promotes insulin resistance, a precursor of type 2 diabetes. We showed that four different statins increased interleukin-1β (IL-1β)...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2014
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db13-1398